A loxP site was inserted downstream of exon 1. A FLAG-tag and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 17. Cre-mediated recombination removed exons 2 through 17 and the neo cassette. (J:192445)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count