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EN
A loxP site was in upstream of the wild-type exon 20, which was followed by a polyadenylation sequence, an FRT-flanked neo cassette, 4x transcriptional STOP, a loxP site and a modified exon 20. The modified exon 20 contained an A to G transition results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination is required to remove the wild-type exon 20 and allow for expression of the modified exon 20. (J:193377)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
