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Cre-mediated recombination and telomere seeding resulted in the transfer a portion of human chromosome 7 (from the AC004922 and AF006752; including the CYP3A cluster) onto the human artificial chromosome (HAC; SC20) generated from human chromosome 14. The HAC contains an GFP, loxP site and hygro cassette at AC004922 locus. A xenobiotic-responsive element results in liver-specific expression of the CYP3A-HAC induced by rifampicin treatment. (J:191214)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
