Gfi1^{tm5.1(GFI1*)Tmo}

Most of the coding sequence was replaced with the corresponding human sequence with a single nucleotide polymorphism of asparagine at position 36 (36N). This variant is associated with increased risk for acute myeloid leukemia in humans. Cre-mediated recombination removed a floxed neo cassette inserted upstream of the last coding exon. (J:192927)