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The insertion vector was approximately 7 kb, containing the CAG promoter and the Diaph3 complete coding sequence. Genotyping by PCR revealed that 10 of 83 potential transgenic founders had integrated the transgene. Five founders transmitted the transgene with offspring born in expected Mendelian ratios. Lines 771 and 924 exhibited hearing loss within the first 16 weeks of life in the F1 generation as detected by auditory brainstem response (ABR) testing and were selected for further analysis. (J:193237)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
