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This mutation was identified among the progeny of a (C3H/HeH x 101/H)F1 male mouse that had received triethylenemelamine on day 1 and hydroxyurea (HU) and HU plus 6 Gy X-rays, at 3-hr intervals, on day 2 and later was mated to tester (PT) females. Cytogenetic analysis indicates that the duplication involves G-bands 1F and 1G and increases the length of Chr 1 by ~10%. The absence of quadrivalents at diakinesis of meiosis I in spermatocytes of an affected male confirms that the additional material is not derived from another chromosome. (J:192801)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
