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This mutation is believed to have originated in a (C3H/HeH x 101/H)F1 female mouse that received 1 Gy X-rays shortly before ovulation and was then mated to a tester (PT) male. The original "mutant" male exhibited a tail kink, but was normal in size. His offspring had normal tails but included one animal with much reduced body weight compared to its sibs; this mouse transmitted the size phenotype. Analysis of G-banded chromosomes from a mouse with this phenotype revealed that Chr 1 is ~30% longer than its normal homolog and appears to contain a duplication either of bands D to E4 or of bands E1 to F. Staining with Chr 1 "paint" confirms that the extra material is of Chr 1 origin. (J:192800)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
