Flanking loxP sites were introduced to the large exon and a floxed neo cassette was inserted into the upstream intron. Cre-mediated recombination removed the neo cassette and left the exon floxed. (J:81816)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count