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An FRT flanked neomycin selection cassette along with a 5' loxP site was inserted in intron 3. In addition, a mutation was inserted in codon 662 in exon 4 resulting in the substitution of a stop codon for one encoding glutamine (Q662X). Correctly targeted mice were crossed to flp deleter mice to excise the selection cassette. A 74 kD protein was produced rather than the 240 kD wild-type protein. (J:191685)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
