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A construct containing a full length cDNA of Zfp423 with a single nucleotide insertion (3877_3878insT) between ZF 27 and ZF 28, corresponding to amino acid 1208 of the protein, followed by an IRES, YFP and a floxed neo selection cassette was inserted into the 5' UTR, replacing the first five exons of the locus. The insertion creates a termination codon and altered reading frame in all reading frames. Cre mediated recombination removed the neo cassette. Western blot analysis confirmed the expression of both inserted proteins. (J:190934)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
