A cre/ERT2 fusion construct followed by an FRT flanked PGK neo selection cassette was inserted into exon 2 at the ATG translational start site. The selection cassette was subsequently removed by crossing properly targeted mice to mice expressing flp recombinase. (J:190366)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count