A loxP site was introduced into intron 6 and a floxed PGK-neo cassette was inserted into intron 7. The selection cassette was removed from properly targeted ES cells leaving exon 7 floxed. (J:139695)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count