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An FRT flanked PGK neo resistance cassette was inserted in intron 2 and loxP sites were inserted flanking exon 3. Subsequent expression of flp recombinase removed the selection cassette leaving exon 3 flanked by loxP sites. Exon 3 contains much of the Il10 interacting domain. Genomic loss of exon 3 was observed in T cells expressing cre under the control of the Cd4 promoter by PCR analysis. (J:189797)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
