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One loxP site was placed upstream of exon 1 while an FRT/loxP flanked neomycin cassette was inserted in intron 2. Correctly targeted mice were mated with flp recombinase expressing mice to excise the neo selection cassette leaving exons 1 and 2 flanked by loxP sites. The flp expressing transgene was then bred away. (J:190168)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
