Tg(Krt18-EGFP,-TAg121)36Ysng

Mice from this transgenic line carry a bacterial artificial chromosome (BAC) containing the mouse keratin 18 gene, into which a loxP-GFP-stop-loxP (LSL) T121 (the N-terminal domain of SV40 large T antigen) cassette was inserted. This line exibits epithelial-specific Cre-dependent expression of T121 to dominantly interfere with all 3 pocket proteins (pRB, p107, and p130), facilitating RB-TS inactivation in vivo with a single construct. One copy of the transgene was observed in mice from line 36. (J:221017)