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Mice from this transgenic line carry a bacterial artificial chromosome (BAC) containing the mouse keratin 18 gene, into which a loxP-GFP-stop-loxP (LSL) T121 (the N-terminal domain of SV40 large T antigen) cassette was inserted. This line exibits epithelial-specific Cre-dependent expression of T121 to dominantly interfere with all 3 pocket proteins (pRB, p107, and p130), facilitating RB-TS inactivation in vivo with a single construct. One copy of the transgene was observed in mice from line 36. (J:221017)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
