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The entire open reading frame of the gene, encoded by a single exon, was replaced with a tTA-IRES-hPLAP-ACN targeting cassette. Tetracycline transactivator (Tta), an internal ribosome entry site (IRES), and human placental alkaline phosphatase (hPLAP) are fused with a self-excising loxP-flanked pol-II promoter-neomycin resistance cassette (ACN). Cre-mediated recombination removed the neo cassette. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
