Transgene
Tg(SOD1*G85R)#Roos
Alias:
G85R
Basic Information
This transgene consists of the human SOD1 carrying a glycine to arginine substitution at amino acid 85 (G86R), a mutation associated with familial amyotrophic lateral sclerosis. In addition, loxP sites were engineered to flank the G86R sequence. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:147156)
Basic Information
MGI ID
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Because of their genetic and physiological similarities with humans, mouse models are essential for understanding human illnesses. Advances in molecular biology and gene editing improve disease replication in mice, allowing researchers to get a better understanding of disease causes, identify biomarkers, and create treatments.
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References
Disease models are key instruments in biomedical research, and their literature reports are critical to the advancement of research. These publications provide researchers with a comprehensive theoretical foundation by detailing the design procedures, application regions, and outcomes analysis of disease models.
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PMID
Journal
Year
IF
