This transgene consists of the human SOD1 carrying a glycine to arginine substitution at amino acid 85 (G86R), a mutation associated with familial amyotrophic lateral sclerosis. In addition, loxP sites were engineered to flank the G86R sequence. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:147156)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count