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A floxed PGk/Tn4 neo cassette and the Akv1-99 murine leukemia virus long terminal repeat were inserted into intron 1 via homologous recombination. The viral long terminal repeat was inserted at the proviral integration site before nucleotide 1062 of the GenBank sequence no. L19607. Cre mediated recombination removed the neo cassette. Q-RT-PCR analysis indicated increased mRNA expression in most tissues in heterozygous and homozygous mice. Western blot analysis confirmed increased protein expression. (J:189834)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
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PMID
Journal
Year
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