Exons 12 through 36 were replaced with a construct containing the human cDNA, a linker sequence, mutated estrogen-binding domain of the estrogen receptor (ERT or ERtm), polyadenylation sequence and floxed neo cassette. The predicted fusion product function depends on tamoxifen treatment. (J:189329)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count