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EN
Most of exon 12 through exon 16 was replaced by a construct containing a human cDNA with point mutations (A to T at the second codon position) that replace tyrosines with alanines at positions 941, 1054, 1197, 1222, 1260, 1276 and 1289 (within YXXM of the PI3K p85 concensus binding sites) and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:189292)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
