Del(Y)3H

This Y Chromosome (Chr) deletion resulted from asymmetric recombination between the short arm of a Y Chr (Yp) of C57BL/6 origin and an X Chr carrying Tp(Y)1CtSxr-a. Whereas Sry (sex determining region of Chr Y) and 16 other single-copy genes and pseudogenes on Yp appear intact by Southern blot analysis, all except a few copies of the Rbmy (RNA binding motif protein, Y Chr) repeat sequence family, which resides between Sry and the centromere and normally comprises at least 50 copies, have been deleted. Sry transcript levels in genital ridges of 11.5 day post coitus (dpc) XXYDel(Y)3H embryos are detectable at much lower levels than in XY embyos; in contrast, transcripts from Kdm5d, which maps distal to Sry between Zfy1 and Zfy2, are similarly abundant in XYDel(Y)3H and XY 11.5 dpc genital ridges. (J:15425, J:29526)