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A 4.4 kb DNA fragment encompassing the Tyrp1 promoter region was cloned into a vector containing the cre/ERT2 sequence. The resulting 7.3 kb construct was purified for microinjection into oocytes and 4 founder lines were generated. Animals from these lines were crossed to mice carrying floxed alleles. Double transgenic offspring were treated with tamoxifen and recombination activity was assessed. One line demonstrated recombination in the pigmented retinal epithelium, but no activity in non-ocular tissues. This line was examined in greater detail. (J:189533)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
