A loxP was inserted in intron 1 and a second loxP followed by an FRT flanked selection cassette were inserted in intron 2. The selection cassette was subsequently removed using flp recombinase. (J:189357)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count