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Exon 10 was replaced with a modified one in which nucleotide substitutions (GAT GGG to GCC GGC) results in the amino acid substitution of alanine for aspartic acid at position 455 (D455A). This modification is predicted to produce a caspase-resistant protein. A floxed neo cassette was inserted downstream of the modified exon 10. (J:189241)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
