The terminal stop codonin exon 5 of the endogenous mouse gene was replaced with an estrogen-dependent cre cDNA (creERT2) preceded in frame by a E2A peptide sequence to interrupt translation between SPC and cre mRNAs coexpressed on a single transcript and followed by a T2A peptide sequence and rtTA. This was then followed by an Frt flanked neo selection cassette. (J:175915)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129 and C57BL/6
Targeted
Insertion
--
1
5
39

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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