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The mouse sequence was mutated to replace glycine with an aspartic acid at position (G90D) and alanine with valine at position 337 (A337V). The second mutation allows for identification with the human-specific antibody. Several lines were establisehd from founders 116 and 202. Line 116 contains two to three more copies of the transgene compared with line 202. (J:188632)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
