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This transgene consists of the entire coding region of human JAK2 with the V617F mutation and the 3' noncoding region under the control of the Vav1 promoter. Line A is expressed in hematopoietic tissues, including the thymus, bone marrow, spleen, peripheral blood, and lymph nodes, but not in various nonhematopoietic tissues except for the lung. The gene copy number for line A is 13 +/- 1.4 based on real-time PCR. (J:135993)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
