A loxP site was inserted usptream of exon 1. A loxp and FRT-flanked neo cassette was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exons 1 and 2 floxed. (J:188023)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count