An FRT-flanked neo cassette with a 5' loxP cassette was inserted upstream of exon 8. An additional loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exons 8 through 11 floxed. These exons code the kinase domain. (J:188476)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count