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EN
Exon 10 was replaced with a floxed neo cassette and a modified exon 10 in which a C to T transition results in the amino acid substitution of leucine for proline at position 301 (P301L). Cre-mediated recombination removed the neo cassette. A 35 kb tandem duplication spans exons in the 3' ends of Mapt and Kansl1. Transcript expression is not effected by this duplication. (J:188213)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
