Psen1^tm1.1Ruvi

Exon 6 was replaced with one in which a point mutation (CTT to CCT) results in the amino acid substitution of proline for leucine at position 166 (L166P), mimicking a mutation found in some familial Alzheimer disease (FAD) patients. Cre-mediated recombination removed the floxed neo cassette. (J:187475)