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A BAC clone containing the murine Klf4 gene was modified by recombineering methods so that a cre recombinase sequence was fused to a tamoxifen-inducible estrogen receptor was inserted at the initial methionine (start codon). The purified construct was injected into fertilized oocytes. Founder animals were generated and cre activity was analyzed by crossing founders to the cre-responsive reporter (ROSA-lacZ) or floxed Klf4 animals. (J:187932, J:188101, J:189337)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
