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A targeting scheme was designed to flank exons 3 and 4 of the gene with loxP sites. A loxP-flanked TK-neomycin cassette was first introduced to intron 4, then excised to leave a single loxP site. The same loxP-flanked TK-neomycin cassette was then placed in intron 2 to create a floxed drug selection marker. Cre-mediated recombination removed the neo cassette and left exons 3 and 4 floxed. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
