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A construct including GFP with a nuclear localization tag and an FRT flanked neo cassette was inserted in frame with the start methionine replacing a genomic fragment including most of exon 1 and all of intron 1 and exon 2. GFP is detected in the nuclei of PECAM+ endocardial and endothelial cells. Quantitative real time PCR and RT-PCR confirmed the absence of full length mRNA expression in tissues from homozygous mice. (J:187714)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
