A single loxP site was inserted upstream of exon 1 and a floxed neomycin resistance cassette was inserted in intron 1. Cre-mediated recombination removed the neo cassette and left exon 1 floxed. (J:201190)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count