A loxP site and flanking XhoI restriction site were introduced in intron 5 and a loxP site and mc1-neo cassette were introduced downstream of the last exon via homologous recombination. (J:187178)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count