Lrp1^b2b1554Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to C substituation at coding nucleotide 12694 in exon 82 of the cDNA (c.12694T>C, NM_008512). This changes the cysteine residue to arginine at position 4232 of the encoded protein (p.C4232R). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Lrp1b2b1554Clo, and may be present in stocks carrying this mutation.