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The cre sequence replaced the beta-galactosidase gene in a plasmid containing the Col11a2 promoter (-742 to +380bp). This construct was injected into fertilized ova to establish a transgenic line. Animals were crossed to reporter mice and at E14.5, cre activity was observed only in flat chondrocytes, prehypertrophic and hypertrophic chondrocytes in limbs and ribs, but not in round choncrocytes at the ends of each primordial cartilage. Some aberrant activity was observed in the forebrain at E12.5. (J:142326)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
