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The cre sequence was inserted into a plasmid between the Col11a2 promoter (-742 to +380bp) and 2.3 kb of the first intron of Col11a2 which acts as an enhancer, replacing the beta-galactosidase (lacz) coding sequence. This construct was injected into fertilized ova to establish a transgenic line. Mice were crossed to reporter mice. At E14.5, cre recombination was observed in all chondrocytes (round, flat, prehypertrophic and hypertrophic chondrocytes) in the limbs and ribs. (J:142326)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
