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Homologous recombination replaced most of exon 2 with an FRT-flanked sequence encoding an HBEGF/EGFP (DTR/EGFP) fusion protein followed by cre recombinase with a nuclear localization signal. A PGK-neo selection cassette was inserted into intron 2. The diphtheria toxin receptor (HBEGF or DTR) is expressed from the Gja10 promoter and can be removed by flp-mediated recombination, leaving cre recombinase under control of the promoter. (J:167075, J:186624)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
