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The recombinase site flanked reporter cassette (FRT site, engrail2 splice acceptor, IRES, LacZ, polyadenylation sequence and loxP site) and selection cassettes (beta-geo, polyadenylation site, FRT site and loxP site) were inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 6. Flp mediated recombination removed the reporter and selection cassettes. Cre-mediated recombination removed exons 5 and 6, which encode the catalytic domain. (J:186412)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
