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An 8.3 kb fragment of the Nphs1 promoter was used to drive podocyte specific cre/EGFP expression in the construct. Three founders were obtained. EGFP immunohistochemistry showed protein expression was restricted to podocytes and was absent from other tissues. When founders were crossed to ROSA26 reporter mice, staining was observed extensively in the glomeruli in all mice (with weak staining observed in the brain, but not in other tissues). A representative line 1 was entered. Mice were backcrossed 10 generations onto FVB/N. (J:185912)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
