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The sequence for icre was inserted into a BAC (RP23-343C17) by recombineering techniques, replacing the sequence between the start codon in exon 2 of the Gcg (glucagon; proglucagon) locus and the stop codon in exon 6. The modified BAC was purified and injected into fertilized oocytes. Four founder lines were established initially and copy numbers were determined (line: 01, 7-8 copies; 12, 2-3; 14, 1; 30, 1). Line 12 was analyzed in detail in the publication. (J:186436)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
