Log In|Sign Up
EN
The transgene comprises the human cytomegalovirus (CMV) immediate early gene promoter followed by an SV40 intron, a cDNA encoding N-terminally hemagglutinin- (HA-) tagged mouse MAP kinase-activated protein kinase 5 (MAPKAPK5) in which leucine at amino acid position 337 has been replaced by alanine (L337A), and an SV40 polyadenylation signal. The L337A amino acid substitution confers constitutive activity on the kinase. Expression of the transgene was confirmed by northern blot analysis of RNA isolated from heart tissue. (J:186303)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
