A loxP site was inserted upstream of exon 1. An FRT flanked neo cassette with a 5' losP site was inserted downstream of exon 1. FLP mediated recombination removed the neo cassette. Cre mediated recombination removed exon 1. (J:186370)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count