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Mouse fertilized oocytes were microinjected with transgene constructs in which the human MHC class II genes HLA-DRA and HLA-DRB1*0405, whose protein products together constitute HLA-DR4, reside downstream of the promoter region (nt -2172 to +12) of the mouse MHC class II Ea gene. The HLA coding sequence, in each case, is inserted into a ~1200 bp segment of the rabbit beta-globin gene which provides an intron, 3'-untranslated region (3'-UTR) and polyadenylation signal. (J:182727, J:186300)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
