A loxP site was inserted upstream of a exon 13. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 15. Cre-mediated recombination removed exons 13 through 15 of Trpv6, exons 17 and 18 of Ephb6 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the epididymis. (J:185629)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
Insertion, Intergenic deletion, Intragenic deletion
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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