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RMCE on KH2 cells, which contain Gt(ROSA)26Sortm1(rtTA*M2)Jae and a FRT-flanked PGK-Neo-pA in the 3' UTR of Col1a1, replaced the FRT-flanked neo cassette with a cassette that contained the tetracycline response element driving inducible expression of the mouse cDNA with nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 127 (S127A). This mutation results in a constitutively active protein. (J:185310)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
