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EN
Recombinase mdiated cassette exchange (RMCE) replaced exon 2 with a loxP site, the human cDNA, an FRT-flanked hygro cassette and a loxP site. Flp-mediated recombination removed the hygro cassette. This knock-in lacks the conserved noncoding sequence 28 (CNS28) region contained in Scn5atm1Rdn. Western blot analysis confirmed increased protein expression in the heart compared to in Scn5atm1Rdn homozygotes. (J:185686)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
