Ruvbl2^M1Btlr

ENU-mutagenesis induced a T to A transversion at position 3147 in the second nucleotide of intron 2. This mutation causes skipping of exon 2 and results in a frameshift upon splicing of exon 1 to exon 3. A premature stop codon following 27 aberrant amino acids encoded by exon 3 and part of exon 4 is expected to cause nonsense-mediated decay of the transcript. (J:185495) Additional incidental mutations were detected in sequencing for the causative mutation, Ruvbl2M1Btlr, and may be present in stocks carrying this mutation.